HORDB

ID: hor005204
Uniprot ID: Q9PRQ9
Protein name: Glucagon
Gene name: gcg
Organism: Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis)
Family: Glucagon family
Source: Animal
Expression: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
Disease: NA
Comments: NA
Taxonomy: Lampetra (genus), Petromyzontidae (family), Petromyzontiformes (order), Hyperoartia (class), Cyclostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Function: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9PRQ9-F1.pdb

hor005204_AF2.pdb

hor005204_ESM.pdb

Mass:	389737	Formula:	C153H226N38O48S
Absent amino acids:	CEPR	Common amino acids:	S
pI:	7.53	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	8
Hydrophobicity:	-67.59	Boman Index:	-5542
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	53.79
Instability Index:	2983.1	Extinction Coefficient cystines:	8480
Absorbance 280nm:	302.86

PubMed ID: 8575665
Title: Characterization of insulin, glucagon, and somatostatin from the river lamprey, Lampetra fluviatilis.